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Article

Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations.

Communications biology - 15 Jan 2026

Cubiella Tamara, Alba-Linares Juan José, San-Juan-Guardado Jaime, Suarez-Priede Alvaro, Gómez-Suárez Nerea, Tous Maria, Bancos Irina, Villabona Carles, Serrano Teresa, Tena Isabel, Del Olmo Maribel, Forga Lluis, Valdés Nuria, Fraga Mario F, Chiara María-Dolores

Abstract excerpt

Pheochromocytomas and paragangliomas (PPGLs) with SDHB mutations frequently develop metastases, but the molecular mechanisms driving this progression remain unclear. Here we show that SDHB-mutant metastatic PPGLs display an amplified hypermethylation signature, particularly in genes involved in neuronal differentiation, building on previous findings in SDHx-mutated tumors. This epigenetic shift is already...

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 41540233
DOI: 10.1038/s42003-026-09543-9
PMCID: PMC12913883

Genes

SDHB
SLC2A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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