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Article

Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.

Neurochemical research - 1 Apr 2016

Saito Yuria, Ishii Kiyo-Aki, Aita Yuichi, Ikeda Tatsuhiko, Kawakami Yasushi, Shimano Hitoshi, Hara Hisato, Takekoshi Kazuhiro

Abstract excerpt

Germline mutations in genes encoding succinate dehydrogenase subunits are associated with the development of familial pheochromocytomas and paragangliomas [hereditary paraganglioma/pheochromocytoma syndrome (HPPS)]. In particular, a mutation in succinate dehydrogenase subunit B (SDHB) is highly associated with abdominal paraganglioma and subsequent distant metastasis (malignant paraganglioma), indicating the...

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Share to Catecholamines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26620190
DOI: 10.1007/s11064-015-1738-3

Genes

SDHB

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Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.PMID 26620190Read ↗

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Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.Semantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

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Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes.Semantic proximity Read ↗

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