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Article

Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS.

International journal of molecular sciences - 5 Jan 2022

Tabebi Mouna, Kumar Dutta Ravi, Skoglund Camilla, Söderkvist Peter, Gimm Oliver

Abstract excerpt

BACKGROUND: Enzymes of tricarboxylic acid (TCA) have recently been recognized as tumor suppressors. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) cause pheochromocytomas and paragangliomas (PCCs/PGLs) and predispose patients to malignant disease with poor prognosis. METHODS: Using the human pheochromocytoma cell line (hPheo1), we knocked down SDHB gene expression using CRISPR-cas9 technology....

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Identifiers

PMID: 35008989
DOI: 10.3390/ijms23010560
PMCID: PMC8745660

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