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The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis

27 Apr 2019

Abstract excerpt

Transformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important SDH mutation is in the SDHD gene, which encodes the smallest subunit of mitochondrial complex II (SDH). It has key...

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PMID: 31372201
DOI: 10.18502/ijhoscr.v13i2.692

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