Article
Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT).
Biochemical pharmacology - 1 Nov 1994
Carrier F, Chang C Y, Duh J L, Nebert D W, Puga A
Abstract excerpt
The aromatic hydrocarbon (Ah) receptor complex is a ligand-activated transcriptional activator consisting of at least two protein components. The ligand-binding component is the AhR protein, a cytosolic receptor encoded by the Ahr gene, which, upon ligand binding, translocates to the nucleus in a...
Topics
- Animals
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Base Sequence
- Binding Sites
- Cell Line
- Cytochrome P-450 Enzyme System
- DNA-Binding Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Polychlorinated Dibenzodioxins
- Receptors, Aryl Hydrocarbon
- Transcription Factors