Article
Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells.
Chemico-biological interactions - 1 Feb 1995
Korkalainen M K, Törrönen A R, Kärenlampi S O
Abstract excerpt
The mouse hepatoma cell line Hepa-1 is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for both CYP1A1 (aryl hydrocarbon hydroxylase, AHH) and class 3 aldehyde dehydrogenase (ALDH3) enzymes. To test the hypothesis of a common regulatory mechanism, several AHH deficient mutants of Hepa-1 w...
Topics
- Aldehyde Dehydrogenase
- Animals
- Aryl Hydrocarbon Hydroxylases
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Blotting, Northern
- Carcinoma, Hepatocellular
- Cell Division
- DNA-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Genes, Neoplasm
- Genes, Recessive
- Liver Neoplasms, Experimental
- Mice
- Mutation
- Polychlorinated Dibenzodioxins
- RNA, Messenger
- Rats
- Receptors, Aryl Hydrocarbon