Aberrant CYP1A1 induction: discrepancy of CYP1A1 mRNA and aryl hydrocarbon hydroxylase activity in mutant cells of mouse hepatoma line, Hepa-1.

doi:10.1111/j.1349-7006.1994.tb02419.x

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Article

Aberrant CYP1A1 induction: discrepancy of CYP1A1 mRNA and aryl hydrocarbon hydroxylase activity in mutant cells of mouse hepatoma line, Hepa-1.

Japanese journal of cancer research : Gann - 1 Jul 1994

Kikuchi H, Usuda M, Sagami I, Ikawa S, Watanabe M

Abstract excerpt

We have isolated new benzo[a]pyrene-resistant clones, cl-21 and cl-32, of the mouse hepatoma line, Hepa-1. CYP1A1-dependent aryl hydrocarbon hydroxylase activity is not inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene in these two cell lines. However, mRNA of CYP1A1 is ind...

Topics

Animals
Aryl Hydrocarbon Hydroxylases
Base Sequence
Benzo(a)pyrene
Blotting, Northern
Blotting, Western
Cytochrome P-450 Enzyme System
DNA, Complementary
Drug Resistance
Hybrid Cells
Liver Neoplasms, Experimental
Mice
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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Identifiers

PMID: 8071113
DOI: 10.1111/j.1349-7006.1994.tb02419.x
PMCID: PMC5919553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8071113-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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