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Article

Aberrant CYP1A1 induction: discrepancy of CYP1A1 mRNA and aryl hydrocarbon hydroxylase activity in mutant cells of mouse hepatoma line, Hepa-1.

Japanese journal of cancer research : Gann - 1 Jul 1994

Kikuchi H, Usuda M, Sagami I, Ikawa S, Watanabe M

Abstract excerpt

We have isolated new benzo[a]pyrene-resistant clones, cl-21 and cl-32, of the mouse hepatoma line, Hepa-1. CYP1A1-dependent aryl hydrocarbon hydroxylase activity is not inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene in these two cell lines. However, mRNA of CYP1A1 is inducible in cl-21 and cl-32 cells, as in the wild-type cells, in spite of an undetectable level of cytosolic Ah receptor....

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Identifiers

PMID: 8071113
DOI: 10.1111/j.1349-7006.1994.tb02419.x
PMCID: PMC5919553

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