Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.

Archives of biochemistry and biophysics - 1 Nov 1991

Piskorska-Pliszczynska J, Morrison V, Zacharewski T, Safe S

Abstract excerpt

Mouse hepatoma Hepa 1c1c7 cells and nonresponsive mutants have been extensively used as models for investigating the molecular mechanism of induction of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Incubation of cytosolic [3H]TCDD-aryl hydrocarbon (Ah) receptor from wild-type Hepa 1c1c7 cells for 16 h at 4 degrees C in 0.4 M KCl resulted in the formation of...

Topics

Animals
Base Sequence
Cell Line
Chromatography, Affinity
Cytosol
DNA-Binding Proteins
Genetic Variation
Liver Neoplasms, Experimental
Mice
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polychlorinated Dibenzodioxins

Receptors, Aryl Hydrocarbon

Receptors, Drug

Tumor Cells, Cultured

Source

Identifiers

PMID: 1656877
DOI: 10.1016/0003-9861(91)90552-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656877-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.PMID 1656877Read ↗

Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells.Semantic proximity Read ↗

Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines.Semantic proximity Read ↗

Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.Semantic proximity Read ↗

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.Semantic proximity Read ↗

Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression.Semantic proximity Read ↗

Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells.Semantic proximity Read ↗

Comparative microarray analysis of basal gene expression in mouse Hepa-1c1c7 wild-type and mutant cell lines.Semantic proximity Read ↗

Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein.Semantic proximity Read ↗

Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin.Semantic proximity Read ↗

Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.Semantic proximity Read ↗

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity.Semantic proximity Read ↗

Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.