Article
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
Archives of biochemistry and biophysics - 1 Nov 1991
Piskorska-Pliszczynska J, Morrison V, Zacharewski T, Safe S
Abstract excerpt
Mouse hepatoma Hepa 1c1c7 cells and nonresponsive mutants have been extensively used as models for investigating the molecular mechanism of induction of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Incubation of cytosolic [3H]TCDD-aryl hydrocarbon (Ah) receptor from wild-type Hepa 1c1c7 cells for 16 h at 4 degrees C in 0.4 M KCl resulted in the formation of...
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