Article
Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line.
Molecular pharmacology - 1 Dec 1996
Zhang J, Watson A J, Probst M R, Minehart E, Hankinson O
Abstract excerpt
Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR). Clones belonging to complementation group B were shown to have reduced lev...
Topics
- Animals
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Butyrates
- Cell Fusion
- Clone Cells
- DNA-Binding Proteins
- Gene Expression Regulation
- Genetic Complementation Test
- HSP90 Heat-Shock Proteins
- Hydroxamic Acids
- Liver Neoplasms, Experimental
- Mice
- Phenotype
- Receptors, Aryl Hydrocarbon
- Transcription Factors
- Tumor Cells, Cultured