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Article

Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.

Human pathology - 1 Jun 2007

Ogino Shuji, Kawasaki Takako, Ogawa Akiyo, Kirkner Gregory J, Loda Massimo, Fuchs Charles S

Abstract excerpt

Overexpression of fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is observed in many cancers including colorectal cancer and is associated with poor clinical outcomes. Cellular FASN expression is physiologically upregulated in a state of energy excess. Obesity and excess energy balance have been known to be risk factors for colorectal cancer. High degree of microsatellite instability (MSI-H) is...

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Topics

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Fatty Acid Synthases

Share to Genes, ras

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 17350669
DOI: 10.1016/j.humpath.2006.11.018

Genes

FASN
BRAF
KRAS
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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