p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.

doi:10.1016/j.celrep.2013.03.028

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Article

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.

Cell reports - 25 Apr 2013

Baker Darren J, Weaver Robbyn L, van Deursen Jan M

Abstract excerpt

BubR1 insufficiency occurs with natural aging and induces progeroid phenotypes in both mice and children with mosaic variegated aneuploidy syndrome. In response to BubR1 insufficiency, skeletal muscle, fat, and lens tissue engage p19(Arf) to attenuate senescence and age-related deterioration. Here, we address how p19(Arf) exerts this caretaker role using BubR1 progeroid mice lacking p53 or its transcriptional...

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Identifiers

PMID: 23602569
DOI: 10.1016/j.celrep.2013.03.028
PMCID: PMC3785294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.