Article
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.
The Journal of cell biology - 13 Feb 2006
Baker Darren J, Jeganathan Karthik B, Malureanu Liviu, Perez-Terzic Carmen, Terzic Andre, van Deursen Jan M A
Abstract excerpt
Aging is a highly complex biological process that is believed to involve multiple mechanisms. Mice that have small amounts of the mitotic checkpoint protein BubR1 age much faster than normal mice, but whether other mitotic checkpoint genes function to prevent the early onset of aging is unknown....
Topics
- Aging, Premature
- Aneuploidy
- Animals
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Haplotypes
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Mutation
- Neoplasms
- Nuclear Matrix-Associated Proteins
- Nucleocytoplasmic Transport Proteins
- Phenotype
- Poly-ADP-Ribose Binding Proteins