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The yin and yang of the Cdkn2a locus in senescence and aging

15 Sept 2008

Abstract excerpt

Senescence of cultured cells involves activation of the p19(Arf)-p53 and the p16(Ink4a)-Rb tumor suppressor pathways. This, together with the observation that p19(Arf) and p16(Ink4a) expression increases with age in many tissues of humans and rodents, led to the speculation that these pathways drive in vivo senescence and natural aging. However, it has been difficult to test this hypothesis using a mammalian...

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PMID: 18769141
DOI: 10.4161/cc.7.18.6687

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