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Article

Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA).

The Journal of biological chemistry - 1 Aug 2008

Binz Sara K, Wold Marc S

Abstract excerpt

Replication protein A (RPA) is the major single-stranded DNA-binding protein in eukaryotes. RPA is composed of three subunits of 70, 32, and 14 kDa. The N-terminal domain of the 70-kDa subunit (RPA70) has weak DNA binding activity, interacts with proteins, and is involved in cellular DNA damage response. To define the mechanism by which this domain regulates RPA function, we analyzed the function of RPA forms...

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Identifiers

PMID: 18515800
DOI: 10.1074/jbc.M802450200
PMCID: PMC2490791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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