Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication.

The Journal of biological chemistry - 30 Sept 1994

Henricksen L A, Wold M S

Abstract excerpt

Replication Protein A (RPA) is a multisubunit, single-stranded DNA-binding protein essential for DNA metabolism in eukaryotic cells. The 32-kDa subunit of RPA is phosphorylated in a cell cycle-dependent manner becoming phosphorylated during S phase. It has been postulated that this phosphorylation may regulate the activities of RPA and that the family of p34cdc2 kinases directly catalyzes the phosphorylation of...

Topics

CDC2 Protein Kinase
Catalysis
Cloning, Molecular
DNA Replication
DNA, Viral
DNA-Binding Proteins
Mutation
Phosphorylation
Replication Protein A
Simian virus 40

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7929076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7929076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication.PMID 7929076Read ↗

Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication CentersSemantic proximity Read ↗

Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication.Semantic proximity Read ↗

Essential functions of the 32 kDa subunit of yeast replication protein A.Semantic proximity Read ↗

In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.Semantic proximity Read ↗

The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break RepairSemantic proximity Read ↗

Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA).Semantic proximity Read ↗

Dissection of functional domains of the human DNA replication protein complex replication protein A.Semantic proximity Read ↗

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Semantic proximity Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression.Semantic proximity Read ↗

In vitro analysis of the zinc-finger motif in human replication protein A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.