Article
Dissection of functional domains of the human DNA replication protein complex replication protein A.
The Journal of biological chemistry - 19 Jul 1996
Lin Y L, Chen C, Keshav K F, Winchester E, Dutta A
Abstract excerpt
Replication protein A (RPA) is a mammalian single-stranded DNA binding factor essential for DNA replication, repair, and recombination. It is composed of three subunits of 70, 34, and 13 kDa (Rpa1, Rpa2, and Rpa3, respectively). Deletion mapping of the Rpa2 subunit identified the domain required...
Topics
- Animals
- Base Sequence
- Chromatography, Affinity
- DNA Helicases
- DNA Primers
- DNA Replication
- DNA-Binding Proteins
- Genotype
- Humans
- Macromolecular Substances
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phosphorylation
- Plasmids
- Polymerase Chain Reaction
- Protein Biosynthesis
- Rabbits
- Recombinant Proteins