Article
Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication.
Nucleic acids research - 1 Aug 1996
Henricksen L A, Carter T, Dutta A, Wold M S
Abstract excerpt
The single-stranded DNA-binding protein, Replication Protein A (RPA), is a heterotrimeric complex with subunits of 70, 32 and 14 kDa involved in DNA metabolism. RPA may be a target for cellular regulation; the 32 kDa subunit (RPA32) is phosphorylated by several cellular kinases including the DNA-...
Topics
- DNA Replication
- DNA, Single-Stranded
- DNA, Viral
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Humans
- Mutation
- Nuclear Proteins
- Phosphorylation
- Protein Binding
- Protein Conformation
- Protein Serine-Threonine Kinases
- Replication Protein A
- Sequence Deletion
- Simian virus 40
- Structure-Activity Relationship