Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines.

doi:10.1016/j.pbb.2008.04.004

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Article

Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines.

Pharmacology, biochemistry, and behavior - 1 Oct 2008

Hitzemann Robert, Malmanger Barry, Belknap John, Darakjian Priscila, McWeeney Shannon

Abstract excerpt

Selective breeding offers several important advantages over using inbred strain panels in detecting genetically correlated traits to the selection phenotype. The purpose of the current study was to selectively breed for prepulse inhibition (PPI) of the acoustic startle response (ASR), to pharmacologically and behaviorally characterize the selected lines and to use the lines for quantitative trait loci (QTL)...

Topics

Acoustic Stimulation
Animals
Antipsychotic Agents
Catalepsy
Central Nervous System Stimulants
Chromosome Mapping
Dizocilpine Maleate
Excitatory Amino Acid Antagonists
Female
Genotype
Haloperidol
Male
Methamphetamine

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Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Inbred DBA

Motor Activity

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Identifiers

PMID: 18513787
DOI: 10.1016/j.pbb.2008.04.004
PMCID: PMC2591930

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