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Article

Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.

Genetics - 1 Dec 2005

Petryshen Tracey L, Kirby Andrew, Hammer Ronald P, Purcell Shaun, O'Leary Sinead B, Singer Jonathan B, Hill Annie E, Nadeau Joseph H, Daly Mark J, Sklar Pamela

Abstract excerpt

Prepulse inhibition (PPI) of acoustic startle is a genetically complex quantitative phenotype of considerable medical interest due to its impairment in psychiatric disorders such as schizophrenia. To identify quantitative trait loci (QTL) involved in mouse PPI, we studied mouse chromosome substitution strains (CSS) that each carry a homologous chromosome pair from the A/J inbred strain on a host C57BL/6J inbred...

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Identifiers

PMID: 15998716
DOI: 10.1534/genetics.105.045658
PMCID: PMC1456091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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