Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitivity to the dopaminergic regulation of prepulse inhibition in rats: evidence for genetic, but not environmental determinants.

Pharmacology, biochemistry, and behavior - 1 Jan 2000

Swerdlow N R, Platten A, Kim Y K, Gaudet I, Shoemaker J, Pitcher L, Auerbach P

Abstract excerpt

Prepulse inhibition (PPI), a measure of sensorimotor gating, is reduced in schizophrenia patients and in rats treated with dopamine (DA) agonists. Reported strain and supplier-based differences in sensitivity to PPI-disruptive effects of DA agonists presumably reflect the differential impact of genetics and/or environment on DAergic substrates regulating PPI. In 2000, Harlan Laboratories established a Texas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Dopamine Agonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Environment

Share to Rats, Long-Evans

Share to Rats, Sprague-Dawley

Share to Reflex, Startle

Share to Species Specificity

Source

Identifiers

PMID: 11701191
DOI: 10.1016/s0091-3057(01)00598-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitivity to the dopaminergic regulation of prepulse inhibition in rats: evidence for genetic, but not environmental determinants.PMID 11701191Read ↗

Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists.Semantic proximity Read ↗

Heritable differences in the effects of amphetamine but not DOI on startle gating in albino and hooded outbred rat strains.Semantic proximity Read ↗

A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.Semantic proximity Read ↗

Strain differences in the gating-disruptive effects of apomorphine: relationship to gene expression in nucleus accumbens signaling pathways.Semantic proximity Read ↗

Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function.Semantic proximity Read ↗

Fronto-temporal-mesolimbic gene expression and heritable differences in amphetamine-disrupted sensorimotor gating in rats.Semantic proximity Read ↗

Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats.Semantic proximity Read ↗

Sensory and sensorimotor gating-disruptive effects of apomorphine in Sprague Dawley and Long Evans rats.Semantic proximity Read ↗

Prepulse inhibition and genetic mouse models of schizophrenia.Semantic proximity Read ↗

Prepulse startle deficit in the Brown Norway rat: a potential genetic model.Semantic proximity Read ↗

Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol.Semantic proximity Read ↗

Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.