Article
Genomic survey of prepulse inhibition in mouse chromosome substitution strains.
Genes, brain, and behavior - 1 Nov 2009
Leussis M P, Frayne M L, Saito M, Berry E M, Aldinger K A, Rockwell G N, Hammer R P, Baskin-Hill A E, Singer J B, Nadeau J H, Sklar P, Petryshen T L
Abstract excerpt
Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre-attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we...
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