Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.

Nature genetics - 1 Jul 2008

Fritsche Lars G, Loenhardt Thomas, Janssen Andreas, Fisher Sheila A, Rivera Andrea, Keilhauer Claudia N, Weber Bernhard H F

Abstract excerpt

Age-related macular degeneration (AMD) is a prevalent multifactorial disorder of the central retina. Genetic variants at two chromosomal loci, 1q31 and 10q26, confer major disease risks, together accounting for more than 50% of AMD pathology. Signals at 10q26 center over two nearby genes, ARMS2 (age-related maculopathy susceptibility 2, also known as LOC387715) and HTRA1 (high-temperature requirement factor A1),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to High-Temperature Requirement A Serine Peptidase 1
Share to Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Models, Biological

Share to Proteins

Share to RNA Stability

Share to Serine Endopeptidases

Share to Tissue Distribution

Source

Identifiers

PMID: 18511946
DOI: 10.1038/ng.170

Genes

ARMS2
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.PMID 18511946Read ↗

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Semantic proximity Read ↗

Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.Semantic proximity Read ↗

Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration.Semantic proximity Read ↗

Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria.Semantic proximity Read ↗

Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?Semantic proximity Read ↗

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration.Semantic proximity Read ↗

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.Semantic proximity Read ↗

Human HtrA1 in the archived eyes with age-related macular degeneration.Semantic proximity Read ↗

The Phenotypic Course of Age-Related Macular Degeneration for ARMS2/HTRA1: The EYE-RISK Consortium.Semantic proximity Read ↗

<i>HTRA1-AS1</i> , an <i>ARMS2</i> -region long non-coding RNA, is downregulated in retinas of age-related macular degeneration patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.