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<i>HTRA1-AS1</i> , an <i>ARMS2</i> -region long non-coding RNA, is downregulated in retinas of age-related macular degeneration patients

2025-11-06

Abstract excerpt

<h4>Purpose</h4> The human 10q26 locus is a major genetic risk factor for age-related macular degeneration (AMD). Fine mapping by linkage and large-scale genome-wide association studies (GWAS) has narrowed this region to a 30-kb interval encompassing the ARMS2 and HTRA1 genes. However, the causative gene(s), risk variants, and underlying pathogenic mechanisms remain unresolved. <h4>Methods</h4> Long non-codin...

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Literature Corpus work
be4c53fb-e51c-5171-bf13-f33b99d0a859
DOI
10.1101/2025.10.29.25338834
Open publication

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<i>HTRA1-AS1</i> , an <i>ARMS2</i> -region long non-coding RNA, is downregulated in retinas of age-related macular degeneration patientsDOI 10.1101/2025.10.29.25338834
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