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Article

Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration.

Human genetics - 1 Mar 2010

Wang Gaofeng, Spencer Kylee L, Scott William K, Whitehead Patrice, Court Brenda L, Ayala-Haedo Juan, Mayo Ping, Schwartz Stephen G, Kovach Jaclyn L, Gallins Paul, Polk Monica, Agarwal Anita, Postel Eric A, Haines Jonathan L, Pericak-Vance Margaret A

Abstract excerpt

Controversy remains as to which gene at the chromosome 10q26 locus confers risk for age-related macular degeneration (AMD) and statistical genetic analysis is confounded by the strong linkage disequilibrium (LD) across the region. Functional analysis of related genetic variations could solve this...

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Identifiers

PMID: 20182747
DOI: 10.1007/s00439-010-0805-8
PMCID: PMC2934780

Genes

ARMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20182747-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration.PMID 20182747Read ↗

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.Semantic proximity Read ↗

Next-generation sequencing analysis of the ARMS2 gene in Turkish exudative age-related macular degeneration patients.Semantic proximity Read ↗

Identification and functional characterization of an AMD associated c-ABL binding SNP streak within the ARMS2 gene promoter regionSemantic proximity Read ↗

AMD-associated variants at the chromosome 10q26 locus and the stability of ARMS2 transcripts.Semantic proximity Read ↗

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Semantic proximity Read ↗

ARMS2 (LOC387715) variants in Japanese patients with exudative age-related macular degeneration and polypoidal choroidal vasculopathy.Semantic proximity Read ↗

Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.Semantic proximity Read ↗

rs10490924 surrounding HTRA1/ARMS2 regulates the susceptibility of age-related macular degeneration.Semantic proximity Read ↗

Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?Semantic proximity Read ↗

Association of LOC387715/ARMS2 (rs10490924) Gene Polymorphism with Age-Related Macular Degeneration in the Brazilian Population.Semantic proximity Read ↗

Association of the del443ins54 at the ARMS2 locus in Indian and Australian cohorts with age-related macular degeneration.Semantic proximity Read ↗

Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular DegenerationSemantic proximity Read ↗

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