Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.

Molecular vision - 15 Jul 2010

Kanda Atsuhiro, Stambolian Dwight, Chen Wei, Curcio Christine A, Abecasis Gonçalo R, Swaroop Anand

Abstract excerpt

PURPOSE: Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD). In different reports, the del443ins54 and rs11200638 variants are suggested to affect ARMS2...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 10
Share to High-Temperature Requirement A Serine Peptidase 1
Share to Macular Degeneration
Share to Placenta
Share to Pregnancy
Share to Proteins
Share to Retina
Share to Serine Endopeptidases

Source

Open in PubMed Open full text

Identifiers

PMID: 20664794
PMCID: PMC2905635

Genes

ARMS2
HTRA1
GAPDH
HPRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.PMID 20664794Read ↗

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.Semantic proximity Read ↗

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.Semantic proximity Read ↗

Human HtrA1 in the archived eyes with age-related macular degeneration.Semantic proximity Read ↗

Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.Semantic proximity Read ↗

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Semantic proximity Read ↗

HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

<i>HTRA1-AS1</i> , an <i>ARMS2</i> -region long non-coding RNA, is downregulated in retinas of age-related macular degeneration patientsSemantic proximity Read ↗

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.Semantic proximity Read ↗

Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration.Semantic proximity Read ↗

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.