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Article

Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria.

Investigative ophthalmology & visual science - 1 Jul 2009

Wang Gaofeng, Spencer Kylee L, Court Brenda L, Olson Lana M, Scott William K, Haines Jonathan L, Pericak-Vance Margaret A

Abstract excerpt

PURPOSE: To analyze the relationship between ARMS2 and HTRA1 in the association with age-related macular degeneration (AMD) in an independent case-control dataset and to investigate the subcellular localization of the ARMS2 protein in an in vitro system. METHODS: Two SNPs in ARMS2 and HTRA1 were...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19255159
DOI: 10.1167/iovs.08-3240
PMCID: PMC3001322

Genes

ARMS2
HTRA1
CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19255159-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria.PMID 19255159Read ↗

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

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Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.Semantic proximity Read ↗

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Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degenerationSemantic proximity Read ↗

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