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The Phenotypic Course of Age-Related Macular Degeneration for ARMS2/HTRA1: The EYE-RISK Consortium.

Ophthalmology - 1 Jul 2022

Thee Eric F, Colijn Johanna M, Cougnard-Grégoire Audrey, Meester-Smoor Magda A, Verzijden Timo, Hoyng Carel B, Fauser Sascha, Hense Hans-Werner, Silva Rufino, Creuzot-Garcher Catherine, Ueffing Marius, Delcourt Cécile, den Hollander Anneke I, Klaver Caroline C W

Abstract excerpt

PURPOSE: Age-related maculopathy susceptibility 2 (ARMS2) is considered the most enigmatic of the genes for age-related macular degeneration (AMD). We investigated the phenotypic course and spectrum of AMD for the risk haplotype at the ARMS2 and high-temperature requirement A serine peptidase 1 (HTRA1) locus in a large European consortium. DESIGN: Pooled analysis of 4 case-control and 6 cohort studies....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35240203
DOI: 10.1016/j.ophtha.2022.02.026

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