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Article

An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 May 2008

Liu Chunqiao, Wang Yanshu, Smallwood Philip M, Nathans Jeremy

Abstract excerpt

Frizzled5 (Fz5), a putative Wnt receptor, is expressed in the retina, hypothalamus, and the parafascicular nucleus (PFN) of the thalamus. By constructing Fz5 alleles in which beta-galactosidase replaces Fz5 or in which Cre-mediated recombination replaces Fz5 with alkaline phosphatase, we observe that Fz5 is required continuously and in a cell autonomous manner for the survival of adult PFN neurons, but is not...

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Identifiers

PMID: 18509025
DOI: 10.1523/JNEUROSCI.1056-08.2008
PMCID: PMC6670808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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