Article
An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 May 2008
Liu Chunqiao, Wang Yanshu, Smallwood Philip M, Nathans Jeremy
Abstract excerpt
Frizzled5 (Fz5), a putative Wnt receptor, is expressed in the retina, hypothalamus, and the parafascicular nucleus (PFN) of the thalamus. By constructing Fz5 alleles in which beta-galactosidase replaces Fz5 or in which Cre-mediated recombination replaces Fz5 with alkaline phosphatase, we observe that Fz5 is required continuously and in a cell autonomous manner for the survival of adult PFN neurons, but is not...
Topics
- Alkaline Phosphatase
- Animals
- Animals, Newborn
- Behavior, Animal
- Cell Survival
- Cells, Cultured
- Central Nervous System
- Embryo, Mammalian
- Estrogen Antagonists
- Frizzled Receptors
- Gene Expression Regulation, Developmental
- Intralaminar Thalamic Nuclei