Article
Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 2002
Wang Yanshu, Thekdi Nupur, Smallwood Philip M, Macke Jennifer P, Nathans Jeremy
Abstract excerpt
Many ligand/receptor families are known to contribute to axonal growth and targeting. Thus far, there have been no reports implicating Wnts and Frizzleds in this process, despite their large numbers and widespread expression within the CNS. In this study, we show that targeted deletion of the mouse fz3 gene leads to severe defects in several major axon tracts within the forebrain. In particular, fz3(-/-) mice...
Topics
- Abnormalities, Multiple
- Animals
- Apoptosis
- Axons
- Cell Division
- Cell Movement
- Central Nervous System
- Cerebral Ventricles
- Frizzled Receptors
- Gene Targeting
- Genes, Reporter