Article

Combined single-cell RNA-seq profiling and enhancer editing reveals critical spatiotemporal controls over thalamic nuclei formation in the murine embryo

2022-02-20

Abstract excerpt

The thalamus is the principal information hub of the vertebrate brain, with essential roles in sensory and motor information processing, attention, and memory. The molecular mechanisms regulating the formation of thalamic nuclei are unclear. We apply longitudinal single-cell RNA-sequencing, regional abrogation of Sonic-hedgehog (Shh), and spatial profiling of gene expression to map the developmental trajectories o...

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Literature Corpus work: 5fed1302-2582-5576-9902-8debec7d16e1
DOI: 10.1101/2022.02.18.481097

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