Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation.

eLife - 17 Mar 2021

Hatch Hayden AM, Belalcazar Helen M, Marshall Owen J, Secombe Julie

Abstract excerpt

Mutations in the lysine demethylase 5 (KDM5) family of transcriptional regulators are associated with intellectual disability, yet little is known regarding their spatiotemporal requirements or neurodevelopmental contributions. Utilizing the mushroom body (MB), a major learning and memory center within the Drosophila brain, we demonstrate that KDM5 is required within ganglion mother cells and immature neurons for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Drosophila
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Histone Demethylases

Share to Mushroom Bodies

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 33729157
DOI: 10.7554/eLife.63886
PMCID: PMC7997662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation.PMID 33729157Read ↗

The Conserved Transcription Factor Krüppel Regulates the Survival and Neurogenesis of Mushroom Body Neuroblasts in <i>Drosophila</i> Adult BrainsSemantic proximity Read ↗

Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons.Semantic proximity Read ↗

Epigenetic regulator KDM5B loss-of-function delays neuronal differentiation of human iPSCsSemantic proximity Read ↗

A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain.Semantic proximity Read ↗

The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila.Semantic proximity Read ↗

Krüppel Regulates Cell Cycle Exit and Limits Adult Neurogenesis of Mushroom Body Neural Progenitors in <i>Drosophila</i>Semantic proximity Read ↗

A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis.Semantic proximity Read ↗

Comparative developmental transcriptomics of <i>Drosophila</i> mushroom body neurons highlights the mevalonate pathway as a regulator of axon growthSemantic proximity Read ↗

Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning.Semantic proximity Read ↗

Identification of mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila.Semantic proximity Read ↗

The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior.Semantic proximity Read ↗

Notch controls early temporal factor expression to control timing of Mushroom body neuroblast apoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.