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Article

Gene expression profile of human endothelial cells exposed to sustained fluid shear stress.

Physiological genomics - 26 Dec 2002

Wasserman Scott M, Mehraban Fuad, Komuves Laszlo G, Yang Ruey-Bing, Tomlinson James E, Zhang Ying, Spriggs Frank, Topper James N

Abstract excerpt

Biomechanical forces can modulate endothelial phenotype through changes in gene expression. We hypothesized that physiological laminar shear stresses (LSS) act as differentiative stimuli on endothelial cells (EC) to alter gene expression, creating an antioxidant, anti-apoptotic and anti-proliferative environment. The transcriptional profile of cultured human umbilical vein endothelial cells (HUVEC) exposed to LSS...

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Source

Identifiers

PMID: 12419857
DOI: 10.1152/physiolgenomics.00102.2002

Genes

LSS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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