Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2021

Maurya Mano R, Gupta Shakti, Li Julie Yi-Shuan, Ajami Nassim E, Chen Zhen B, Shyy John Y-J, Chien Shu, Subramaniam Shankar

Abstract excerpt

The two main blood flow patterns, namely, pulsatile shear (PS) prevalent in straight segments of arteries and oscillatory shear (OS) observed at branch points, are associated with atheroprotective (healthy) and atheroprone (unhealthy) vascular phenotypes, respectively. The effects of blood flow-induced shear stress on endothelial cells (ECs) and vascular health have generally been studied using human umbilical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Human Umbilical Vein Endothelial Cells

Share to Metabolic Networks and Pathways

Share to Proteome

Share to Stress, Mechanical

Share to Systems Biology

Source

Open in PubMed Open full text

Identifiers

PMID: 33468662
DOI: 10.1073/pnas.2023236118
PMCID: PMC7848718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions.PMID 33468662Read ↗

Systems biology analysis of longitudinal functional response of endothelial cells to shear stressSemantic proximity Read ↗

Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosisSemantic proximity Read ↗

Mechanotransduction of shear in the endothelium: Basic studies and clinical implicationsSemantic proximity Read ↗

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cellsSemantic proximity Read ↗

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology.Semantic proximity Read ↗

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculatureSemantic proximity Read ↗

Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development.Semantic proximity Read ↗

Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeuticsSemantic proximity Read ↗

Endothelial fluid shear stress sensing in vascular health and diseaseSemantic proximity Read ↗

Shear stress-initiated signaling and its regulation of endothelial function.Semantic proximity Read ↗

Adaptive response of vascular endothelial cells to an acute increase in shear stress magnitude.Semantic proximity Read ↗

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.