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Article

Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.

The Journal of infectious diseases - 1 May 1991

Kaatz G W, Seo S M, Ruble C A

Abstract excerpt

Fluoroquinolone resistance that arose in the test strain during ciprofloxacin therapy of experimental Staphylococcus aureus endocarditis was studied. In two isolates, resistance was due to a decreased sensitivity of the process of DNA synthesis to fluoroquinolones, suggesting the presence of an altered DNA gyrase. Another isolate had an enhanced energy-dependent mechanism, possibly an efflux system, by which...

Topics

Ampicillin
Anti-Infective Agents
Bacterial Proteins
Ciprofloxacin
Cloning, Molecular
DNA Topoisomerases, Type II
DNA, Bacterial
Drug Resistance, Microbial
Humans
Membrane Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Norfloxacin

Nucleic Acid Hybridization

R Factors

Restriction Mapping

Staphylococcus aureus

Source

Identifiers

PMID: 1850442
DOI: 10.1093/infdis/163.5.1080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850442-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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