Article
Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Sept 1997
Zeller V, Janoir C, Kitzis M D, Gutmann L, Moreau N J
Abstract excerpt
The accumulation of fluoroquinolones (FQs) was studied in a FQ-susceptible laboratory strain of Streptococcus pneumoniae (strain R6). Uptake of FQs was not saturable, was rapidly reversible, and appeared to occur by passive diffusion. In the presence of glucose, which energizes bacteria, the uptake of FQs decreased. Inhibitors of the proton motive force and ATP synthesis increased the uptake of FQs in previously...
Topics
- 4-Quinolones
- Acriflavine
- Adenosine Triphosphate
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Carbonyl Cyanide m-Chlorophenyl Hydrazone
- Cetrimonium
- Cetrimonium Compounds
- Ciprofloxacin
- Drug Resistance, Microbial