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Article

Mechanisms of resistance to the 4-quinolone antibacterial agents.

The Journal of antimicrobial chemotherapy - 1 Dec 1990

Crumplin G C

Abstract excerpt

Because of the close structural relationship of the fluorinated 4-quinolones to the parent compound nalidixic acid the mechanism of resistance is often perceived to be the same. However, it is clear that whilst the mechanism of resistance to fluorinated 4-quinolones is essentially the same, strains that are selected as resistant to nalidixic acid generally retain sensitivity to the newer agents. A number of...

Topics

4-Quinolones
Anti-Infective Agents
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Escherichia coli
Humans
Mutation
Time Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1963425
DOI: 10.1093/jac/26.suppl_f.131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1963425-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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