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Article

Mechanisms of resistance to the 4-quinolone antibacterial agents.

The Journal of antimicrobial chemotherapy - 1 Dec 1990

Crumplin G C

Abstract excerpt

Because of the close structural relationship of the fluorinated 4-quinolones to the parent compound nalidixic acid the mechanism of resistance is often perceived to be the same. However, it is clear that whilst the mechanism of resistance to fluorinated 4-quinolones is essentially the same, strains that are selected as resistant to nalidixic acid generally retain sensitivity to the newer agents. A number of...

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PMID: 1963425
DOI: 10.1093/jac/26.suppl_f.131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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