Article
Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance phenotype of Pseudomonas aeruginosa G49.
FEMS microbiology letters - 15 Sept 1996
Pumbwe L, Everett M J, Hancock R E, Piddock L J
Abstract excerpt
A clinical isolate of Pseudomonas aeruginosa G48, became resistant during fluoroquinolone treatment giving rise to the post-therapy isolate, G49. To determine whether mutation in gyrA gave rise to fluoroquinolone resistance, G49 was transformed with a plasmid encoding gyrA (pNJR3-2); this reduced...
Topics
- Anti-Infective Agents
- Base Sequence
- DNA Gyrase
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Multiple
- Fluoroquinolones
- Genes, Bacterial
- Humans
- Mutation
- Phenotype
- Plasmids
- Porins
- Pseudomonas Infections
- Pseudomonas aeruginosa
- Transformation, Genetic