Article
A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Leon Wanda Carolina, Canneva Fabio, Partridge Vanessa, Allard Simon, Ferretti Maria Teresa, DeWilde Arald, Vercauteren Freya, Atifeh Ramtin, Ducatenzeiler Adriana, Klein William, Szyf Moshe, Alhonen Leena, Cuello A Claudio
Abstract excerpt
Alzheimer's disease (AD) is a neurodegenerative pathology in which amyloid-beta (Abeta) peptide accumulates in different brain areas leading to deposition of plaques and a progressive decline of cognitive functions. After a decade in which a number of transgenic (Tg) mouse models mimicking AD-like amyloid-deposition pathology have been successfully generated, few rat models have been reported that develop...
Topics
- Age Factors
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Cerebral Cortex
- Cognition Disorders
- Disease Models, Animal
- Female