Article
Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Ruiz-Opazo Nelson, Kosik Kenneth S, Lopez Lyle V, Bagamasbad Pia, Ponce Lorenz Rb, Herrera Victoria Lm
Abstract excerpt
Alzheimer's disease (AD) is characterized by increased beta amyloid (Abeta) levels, extracellular Abeta deposits in senile plaques, neurofibrillary tangles, and neuronal loss. However, the physiological role of normal levels of Abeta and its parent protein, the amyloid precursor protein (APP) are unknown. Here we report that low-level transgenic (Tg) expression of the Swedish APP mutant gene (APPswe) in...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Animals, Genetically Modified
- Brain
- Cognition
- Food Preferences
- Hippocampus
- Male
- Maze Learning
- Memory
- Mutation