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Article

Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Ruiz-Opazo Nelson, Kosik Kenneth S, Lopez Lyle V, Bagamasbad Pia, Ponce Lorenz Rb, Herrera Victoria Lm

Abstract excerpt

Alzheimer's disease (AD) is characterized by increased beta amyloid (Abeta) levels, extracellular Abeta deposits in senile plaques, neurofibrillary tangles, and neuronal loss. However, the physiological role of normal levels of Abeta and its parent protein, the amyloid precursor protein (APP) are unknown. Here we report that low-level transgenic (Tg) expression of the Swedish APP mutant gene (APPswe) in...

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Identifiers

PMID: 15502881
DOI: 10.2119/2003-00044.herrera
PMCID: PMC1431353

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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