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Article

Myristoylation is important at multiple stages in poliovirus assembly.

Journal of virology - 1 May 1991

Moscufo N, Simons J, Chow M

Abstract excerpt

The N-terminal glycine of the VP4 capsid subunit of poliovirus is covalently modified with myristic acid (C14 saturated fatty acid). To investigate the function of VP4 myristoylation in poliovirus replication, amino acid substitutions were placed within the myristoylation consensus sequence at the alanine residue (4003A) adjacent to the N-terminal glycine by using site-directed mutagenesis methods. Mutants which...

Topics

Amino Acid Sequence
Base Sequence
DNA, Viral
HeLa Cells
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Myristic Acids
Phenotype
Plasmids
Poliovirus
Virus Replication

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Identifiers

PMID: 1850017
DOI: 10.1128/JVI.65.5.2372-2380.1991
PMCID: PMC240589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Myristoylation is important at multiple stages in poliovirus assembly.PMID 1850017Read ↗

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