Article
Sequence-independent acylation of the vaccinia virus A-type inclusion protein.
Biochemistry - 6 Jul 2004
Yoder Jennifer D, Chen Tsefang, Hruby Dennis E
Abstract excerpt
N-Terminal myristoylation of proteins typically occurs cotranslationally via an amide bond to the penultimate glycine residue within the canonical motif (M)GXXX(S/T/A) in a reaction catalyzed by N-myristoyltransferase. A second, less common myristoylation reaction occurs internally at dibasic amino acid doublets of proteins such as alpha-TNF. In this case, myristoylation occurs within a portion of the preprotein,...
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