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Inhibition of vaccinia virus L1 <i>N</i> -myristoylation by the host <i>N</i> -myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry

2022-06-13

Abstract excerpt

<h4>ABSTRACT</h4> We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N- myristoylation of viral proteins by human host cell N -myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT inhibitor. Here, we reveal the role of N -myristoylation during vaccinia virus (VACV) infection...

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Literature Corpus work
8035b0f2-4afd-592d-b54b-d95430d62580
DOI
10.1101/2022.06.13.495866
Open publication

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Inhibition of vaccinia virus L1 <i>N</i> -myristoylation by the host <i>N</i> -myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entryDOI 10.1101/2022.06.13.495866
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