Article
Palmitoylation of SARS-CoV-2 Envelope protein is central to virus particle formation.
Journal of virology - 22 Oct 2024
Wang Zhaohuan, Qiu Manman, Ji Yue, Chai Keli, Liu Chenxi, Xu Fengwen, Guo Fei, Tan Juan, Liu Ruikang, Qiao Wentao
Abstract excerpt
The Envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an integral structural protein in the virus particles. However, its role in the assembly of virions and the underlying molecular mechanisms are yet to be elucidated, including whether the function of E protein is regulated by post-translational modifications. In the present study, we report that SARS-CoV-2 E protein is...
Topics
- Lipoylation
- Humans
- SARS-CoV-2
- Virus Assembly
- Coronavirus Envelope Proteins
- Virion
- Acyltransferases
- COVID-19
- HEK293 Cells
- Protein Processing, Post-Translational
- Spike Glycoprotein, Coronavirus
- Mutation
