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Article

Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

Bryant M, Ratner L

Abstract excerpt

Covalent linkage of myristic acid to the N-terminal glycine residue of Pr55gag, the precursor of the major structural proteins of human immunodeficiency virus 1 (HIV-1), facilitates an essential step in virus assembly and propagation. Substitution of the myristoyl-acceptor glycine with alanine, in a functional clone of HIV-1, eliminates virus replication. Complementation of this defect, in trans, restores...

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Identifiers

PMID: 2405382
DOI: 10.1073/pnas.87.2.523
PMCID: PMC53297

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Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.PMID 2405382Read ↗

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