Article
Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly.
AIDS research and human retroviruses - 1 Jun 1990
Pal R, Reitz M S, Tschachler E, Gallo R C, Sarngadharan M G, Veronese F D
Abstract excerpt
The gag proteins of HIV-1 are modified by the addition of myristic acid to the amino terminal glycine residue. Site-directed mutagenesis was used to construct a mutant of HIV-1 in which this glycine residue was changed to an alanine. Upon transfection into cos-1 cells, the mutant genome directed...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Viral
- Gene Products, gag
- HIV Antigens
- HIV-1
- Humans
- Lipid Bilayers
- Molecular Sequence Data
- Mutation
- Myristic Acid
- Myristic Acids
- Subcellular Fractions
- Transfection
- Viral Proteins
- gag Gene Products, Human Immunodeficiency Virus