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Article

Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly.

AIDS research and human retroviruses - 1 Jun 1990

Pal R, Reitz M S, Tschachler E, Gallo R C, Sarngadharan M G, Veronese F D

Abstract excerpt

The gag proteins of HIV-1 are modified by the addition of myristic acid to the amino terminal glycine residue. Site-directed mutagenesis was used to construct a mutant of HIV-1 in which this glycine residue was changed to an alanine. Upon transfection into cos-1 cells, the mutant genome directed the synthesis of the full complement of HIV-1 proteins, but p17 and p17-containing polyproteins were not myristoylated....

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Identifiers

PMID: 2194551
DOI: 10.1089/aid.1990.6.721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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