Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles.

doi:10.1128/JVI.64.9.4099-4107.1990

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Article

Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles.

Journal of virology - 1 Sept 1990

Marc D, Masson G, Girard M, van der Werf S

Abstract excerpt

We previously described the generation of a set of mutations into a cDNA of poliovirus type 1 in the myristoylation signal of the capsid polypeptide VP4 (D. Marc, G. Drugeon, A.-L. Haenni, M. Girard, and S. van der Werf, EMBO J. 8:2661, 1989). Genomic transcripts synthesized in vitro from the mutated cDNAs were found to be noninfectious upon transfection of permissive cells, and this property correlated with the...

Topics

Amino Acid Sequence
Capsid
Cloning, Molecular
Escherichia coli
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Myristic Acid
Myristic Acids
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poliovirus

RNA, Viral

Transcription, Genetic

Transfection

Viral Proteins

Virion

Source

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Identifiers

PMID: 2166807
DOI: 10.1128/JVI.64.9.4099-4107.1990
PMCID: PMC247872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2166807-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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