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Article

Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles.

Journal of virology - 1 Sept 1990

Marc D, Masson G, Girard M, van der Werf S

Abstract excerpt

We previously described the generation of a set of mutations into a cDNA of poliovirus type 1 in the myristoylation signal of the capsid polypeptide VP4 (D. Marc, G. Drugeon, A.-L. Haenni, M. Girard, and S. van der Werf, EMBO J. 8:2661, 1989). Genomic transcripts synthesized in vitro from the mutated cDNAs were found to be noninfectious upon transfection of permissive cells, and this property correlated with the...

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Identifiers

PMID: 2166807
DOI: 10.1128/JVI.64.9.4099-4107.1990
PMCID: PMC247872

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Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles.PMID 2166807Read ↗

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