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Article

The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability.

The Journal of biological chemistry - 1 Aug 2008

Rajabi Mohsen, de Leeuw Erik, Pazgier Marzena, Li Jing, Lubkowski Jacek, Lu Wuyuan

Abstract excerpt

Mammalian alpha-defensins, expressed primarily in leukocytes and epithelia, play important roles in innate and adaptive immune responses to microbial infection. Six invariant cysteine residues forming three indispensable disulfide bonds and one Gly residue required structurally for an atypical beta-bulge are totally conserved in the otherwise diverse sequences of all known mammalian alpha-defensins. In addition,...

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Identifiers

PMID: 18499668
DOI: 10.1074/jbc.M801851200
PMCID: PMC2490794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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