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Article

Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.

The Journal of biological chemistry - 22 Jun 2012

Rajabi Mohsen, Ericksen Bryan, Wu Xueji, de Leeuw Erik, Zhao Le, Pazgier Marzena, Lu Wuyuan

Abstract excerpt

Human α-defensins are cationic peptides that self-associate into dimers and higher-order oligomers. They bind protein toxins, such as anthrax lethal factor (LF), and kill bacteria, including Escherichia coli and Staphylococcus aureus, among other functions. There are six members of the human α-defensin family: four human neutrophil peptides, including HNP1, and two enteric human defensins, including HD5. We...

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Identifiers

PMID: 22573326
DOI: 10.1074/jbc.M112.367995
PMCID: PMC3381126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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