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Article

Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?

The Journal of biological chemistry - 30 Dec 2005

Wu Zhibin, Li Xiangqun, de Leeuw Erik, Ericksen Bryan, Lu Wuyuan

Abstract excerpt

Mammalian alpha-defensins, expressed primarily in leukocytes and epithelia, kill a broad range of microbes, constituting one of the first lines of innate immune defense against infection. Nine amino acid residues, including six cysteines, one glycine, and a pair of oppositely charged residues Arg/Glu, are conserved in the otherwise diverse sequences of all known mammalian alpha-defensins. Structural analysis...

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PMID: 16246847
DOI: 10.1074/jbc.M510562200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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