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Article

Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity.

Viruses - 29 Aug 2017

Valere Kimyata, Lu Wuyuan, Chang Theresa L

Abstract excerpt

Defensins are antimicrobial peptides important for mucosal innate immunity. They exhibit a broad spectrum of activity against bacteria, viruses, and fungi. Levels of α-defensins are elevated at the genital mucosa of individuals with sexually transmitted infections (STIs). Somewhat paradoxically, human α-defensin 5 and 6 (HD5 and HD6) promote human immunodeficiency virus (HIV) infectivity, and contribute to...

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Identifiers

PMID: 28850095
DOI: 10.3390/v9090244
PMCID: PMC5618010

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